In this task, you will identify a healthcare problem and develop a PICO question that can be answered using evidence. You will identify a single intervention and then search for five research articles and two non-research articles that support that change practice. ***Here is the PICO to use, the attached five research articles, and two non-research articles that support that change of practice. Please feel free to adjust as you see necessary. P(population)= neonatal population with apnea of prematurity I(current intervention)= Current common intervention Theophylline C(compare/alternative)= Is caffeine a better Methylxanthine to treat apnea of prematurity O(outcome)= Reduce apnea of prematurity Question: Is Caffeine more effective than Theophylline in reducing the occurrence of apnea in neonatal patients with apnea of prematurity? 5 Research articles: 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408648/ 2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111868/ 3. https://www.pediatr-neonatol.com/article/S1875-9572(17)30177-8/pdf 4.https://pdfs.semanticscholar.org/89a1/2611bc690daaf5cd2de5cc301cb98c9d83cd.pdf 5. https://www.pediatr-neonatol.com/article/S1875-9572(17)30805-7/fulltext 2 Non Research Articles: 1. https://www.stanfordchildrens.org/en/topic/default?id=apnea-of-prematurity-90-P02922 2. https://www.hopkinsallchildrens.org/Patients-Families/Health-Library/HealthDocNew/Apnea-of-Prematurity ASSIGNMENT REQUIREMENTS You must use the rubric to direct the creation of your submission because it provides detailed criteria that will be used to evaluate your work. Each requirement below may be evaluated by more than one rubric aspect. The rubric aspect titles may contain hyperlinks to relevant portions of the course. A. Write a summary of the significance and background of a healthcare problem by doing the following: 1. Describe a healthcare problem that can be used to develop a PICO question. 2. Explain the significance of the problem from part A1. 3. Describe the current healthcare practices related to the problem from part A1. 4. Discuss how the problem affects the organization and patients cultural background (i.e., values, health behavior, and preferences). B. Complete a literature review by searching for a total of seven articles consisting of five research articles and two non-research articles related to the healthcare problem from part A1, and describe the search strategy you used to conduct the literature review by doing the following: 1. Discuss two research evidence sources and two nonresearch evidence sources that you considered. Note: Please do not use the same primary author for more than two articles. Articles must not be more than five years old. C. Use your research articles to develop a PICO (patient/population, intervention/indicator, comparison/control, and outcome) question based on the topic. D. Complete the attached Evidence Matrix, using the five research evidence sources from scholarly journal sources you located during the literature review in part B. For each article, address the following points: Note: You may submit your completed matrix as a separate attachment to the task, or you may include the matrix within your paper, aligned to APA formatting standards. author, journal name, and year of publication research design (e.g., quantitative, qualitative, mixed design, systematic review) sample size (e.g., numbers of study participants, number of articles, number of control group participants) outcome variables measured (e.g., identify what the research is measuring) quality (using the following scale: A, B, C) results/authors conclusions (e.g., briefly summarize the outcome) E. Recommend a practice change that addresses the PICO question, using the evidence collected in the attached Evidence Matrix. You must use all five research articles from the Evidence Matrix attachment to support this recommendation via in-text citations. F. Describe a process for implementing the practice change from part E in which you do the following: 1. Explain how you would involve three key stakeholders in the decision to implement the recommendation from part E. 2. Describe two specific barriers you may encounter when implementing the practice change from part E in the nursing practice setting. 3. Identify two strategies that could be used to overcome the barriers described in part F2. 4. Identify one indicator to measure the outcome (the O in PICO question) of the recommended change practice from part E. G. Acknowledge sources, using APA-formatted in-text citations and references, for content that is quoted, paraphrased, or summarized. H. Demonstrate professional communication in the content and presentation of your submission. RUBRIC A1:HEALTHCARE PROBLEMS The described healthcare problem contains enough detail that it can be used to develop a PICO question. The described healthcare problem is one that is currently prioritized in healthcare organizations. A2:SIGNIFICANCE OF PROBLEM The explanation thoroughly addresses the significance of the problem described in part A1. The explanation contains enough detail to address the significance of the problem described in part A1. A3:CURRENT PRACTICE The description incorporates specific examples of the current healthcare practices related to the described problem from part A1. A4:IMPACT ON BACKGROUND The discussion incorporates specific details of how the problem affects the organization and specific examples of how the problem impacts the patients cultural background. B1:EVIDENCE SOURCES The discussion of 2 research evidence sources and 2 nonresearch evidence sources conveys a level of understanding in relation to appropriate scholarly and secular sources. C:PICO QUESTION The developed question includes all elements of PICO (patient/population, intervention/indicator, comparison/control, and outcome), is based on the topic and uses research from part B. D:EVIDENCE MATRIX The Evidence Matrix attachment includes the 5 sources from part B, and the scholarly journal sources are located in major medical databases. All of the given points are accurately or logically addressed for each source. E:RECOMMENDED PRACTICE CHANGE The recommended practice change is an logical outcome of the PICO question and is supported by the evidence collected in the Evidence Matrix attachment. All 5 research articles from the Evidence Matrix attachment are used via in-text citations to support the recommendation. F1 :KEY STAKEHOLDERS The explanation shows an effective way for 3 key stakeholders to be involved in the decision to implement the recommendation from part E. F2:BARRIERS The description addresses 2 plausible barriers that may be encountered when implementing the practice change from part E in a nursing practice setting. F3:STRATEGIES FOR BARRIERS 2 strategies that could be used to overcome the barriers described in part F2 are identified. F4:INDICATOR TO MEASURE OUTCOME The 1 identified indicator would measure the outcome of the recommended practice change from part E. G:APA SOURCES The submission includes in-text citations and references for content that is quoted, paraphrased, or summarized and demonstrates a consistent application of APA style. H:PROFESSIONAL COMMUNICATION Content reflects attention to detail, is organized, and focuses on the main ideas as prescribed in the task or chosen by the candidate. Terminology is pertinent, is used correctly, and effectively conveys the intended meaning. Mechanics, usage, and grammar promote accurate interpretation and understanding.