Describe the NF-kappaB signalling pathway and explain the process of activation at cellular level upon detection of bacterial pathogen antigens.
Inhibition of intestinal inflammation by bacterial pathogen effector NleE
1- Give an overview of the role of inflammation in control of intestinal microbiota (pathogens and commensals).
2- Explain the role of host cell surface and intracellular receptors involved in detecting invading pathogens and activating the inflammatory pathways.
3- Describe the NF-kappaB signalling pathway and explain the process of activation at cellular level upon detection of bacterial pathogen antigens.
4- Discuss the effector (NleE) and present the pathogen.
5- Explain how the effector has been identified and its role in control of inflammation discovered.
6- Explain the mode of action of the effector and discuss its role in pathogenesis.
7- Discuss how this discovery could be exploited for therapeutic purpose (in the last chapter.)
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