Can ethylene glycol poisoning be prevented by intoxicating concentrations of ethanol?
Ethanol is metabolized by alcohol dehydrogenase and aldehyde dehydrogenase to acetate which can be Show more Ethanol is metabolized by alcohol dehydrogenase and aldehyde dehydrogenase to acetate which can be susequently converted to acetyl-CoA. Ethylene glycol (an automotive antifreeze) is poisonous and oxidized to oxalic acid (as oxalate) a toxic compound found in rhubarb leaves and many other plants. Ethylene glycol is metabolized by the same enzymes as ethanol producing glycolate which is further oxidized to oxalate and not further metabolized. a) Write the reactions involved in Ethylene glycol conversion and explain also why its metabolism is not energetically favorable. b) Can ethylene glycol poisoning be prevented by intoxicating concentrations of ethanol? If yes why? Show less
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