Explain this observation and the possible pathological and genetic signifi cance of the fi nding of two bands in an African American female.
Glucose-6-phosphate dehydrogenase (G6PD) is encoded by an X-linked gene. G6PD loss-of-function mutat Show more Glucose-6-phosphate dehydrogenase (G6PD) is encoded by an X-linked gene. G6PD loss-of-function mutations can lead to hemolysis on exposure to some drugs fava beans and other compounds (see Chap. 18). Electrophoresis of red blood cell hemolysates shows that some females have two G6PD bands but males have a single band. Explain this observation and the possible pathological and genetic signifi cance of the fi nding of two bands in an African American female. Show less
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