provide benefits of malarone against cholorquine with less side effects and useful in resistance of cholorquine for treating malaria

please provide benefits of malarone against cholorquine with less side effects and useful in resistance of cholorquine for treating malaria by these studies: 1- a systematic review and meta-analysis of the effectiveness & safety of a tovaquone- proguanil ( malarone) for chemoprophylaxis against malaria (2007) by nakato. 2- atovaquone- proguanil versus cholorquine- proguanil for malaria prophylaxis in non-immune travellers: a randomized, double blind study (2000) by lancet.

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